i3S achieves oriented cell division

12 April 2024 09:26

Porto - Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), a research institute based in Portugal, has published a study in which it is revealed that epidermal stem cells divide can be led to divide in a specific direction. The findings of this research have been published in the trade journal “GENETICS”.

Based in Porto the research institute i3S, which focuses on cell division mechanisms, has succeeded in its attempts to ensure that epidermal stem cells divide in a specific direction. According to a press release, the study, which has been published in the trade journal “GENETICS”, shows how a motor protein in conjunction with a cell shape signals enable epidermal stem cells to divide in the correct direction.

Through oriented cell divisions, tissues can acquire their proper size, shape and cellular diversity. Cell division of this kind can often be observed in stem cells, in which one daughter cell retains its stem cell potential, while the second differentiates in terms of its structure. A detailed study of these molecular mechanisms of spindle orientation is crucial for understanding the formation and maintenance of tissues. In this way, insights into defective regulation and the formation of defects that contribute to carcinogenesis can also be generated. ce/eb

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